![]() This version integrates many of the mobile features which make the transition between desktop and phone pretty seamless. ![]() With the PC version of WhatsApp, you've got access to all of your contacts that you would normally chat with on the mobile application directly from your desktop. This will allow you to scan the QR code that the Windows client is displaying. To get the QR code and connect to your PC, click the settings icons in WhatsApp and select - WhatsApp Web. The main interface will then be populated with your contacts and chat history. Get the application up and running by scanning a QR code from your screen on your phone and you'll then be authorized to use WhatsApp for PC connected to your cell phone number. Getting started with this chat client is quite simple. It's more often than not used on mobile platforms such as Android and iOS but WhatsApp has developed a version for Windows which can synchronize with your mobile phone. WhatsApp for PC is the desktop version of the popular instant messaging application owned by Facebook. If you don't have a mouse with adjustable sensitivity, you may run into trouble, as the game was designed for mice with very low DPI and thus has very slow mouse movement on any kind of modern gaming mouse (unless you hit that button a few times).A popular messaging app used as a free alternative to SMS messages. Just in case you only have integrated graphics, you may have to turn down some of the particle effects (as is often the case with alpha transparency heavy PS2-ports from that era), but otherwise, it has low hardware requirements, of course. This game is from before single-use activation codes became standard, so a used PC copy should install just fine.ĭo note that you need this fan patch on PC in order for it to work at all on modern hardware: I recommend either the excellent Wii port if you want a console version (the PS2 version works, but runs at a resolution and frame rate that would make even Cyberpunk 2077 blush) or the best version, which is of course the PC port. Most licensing contracts are only for a few years or a limited number of copies, which is a shame with great games like this one. This is often the case with movie tie-ins like this one, but also games that contain copyrighted music, cars or brands. The game is not available anymore due to expired licenses. ![]() The developers get exactly the same amount of money as if you pirated it though, so unless piracy = stealing in your mind (even though you aren't taking anything away and are not depriving anyone of their income), it really doesn't matter. The only legal way is to buy a used copy. Please mark an answered submission with the (✔ Answered) Flair./r/GamingStories - About sharing our gaming experiences.Īlso of interest is the PC Gaming Wiki for tweaks and fixes of many PC games./r/tipofmyjoystick - Like tipofmytongue, just for games./r/tipofmytongue for when you can't quite remember that game from your youth./r/shouldibuythisgame for those times you want to spend your money wisely./r/GamingSuggestions for when you want to pick up a new title./r/TrueGaming for the more philosophical type questions./r/Gaming and /r/Games for anything gaming related.Try and search if your questions has been asked already before posting.ĪskGames Wiki is a good starting place to check first.If you don't know the answer yourself but know of a subreddit that might, mention it.Do not downvote any questions you think are dumb or simple.Once your query is answered, use the Link Flair "✔ Answered" to mark it as such.When asking questions for technical help please try to give as much information as possible. ![]() However all kinds of gaming-related questions are welcome. How do I get the "Kill everything" achievement?. ![]() Sort of like /r/AskReddit, but for games and gamers. ![]()
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![]() ![]() Not all of these areas need to feature in the tool – you can omit/add categories depending on the basic information you have about your client and proceed from there. These are the areas that commonly feature in this tool: So, the Wellness Wheel needs to be divided into equal number of segments. It becomes a quick and simple tool to pick up during a discovery session – not only to help the client assess what area they need to immediately focus on, but also for the coach to figure out whether or not they can or are equipped to handle that segment of the client’s life.Īsking insightful life coaching questions is an art… …an art that you can learn easily with the help of our guide! Download the Free Guide How Does It Work While there is no restriction or rule on when the Wheel of Life can or should be used during a coaching engagement, it proves to be rather helpful to employ it at the very beginning of the engagement – preferably even before the first official session. In the coaching context, the wheel of life coaching tool is particularly useful if you find that your client is at a junction where they are not able to figure out or focus on what they need to address first among the multiple things they’d like to fix/solve in their lives.įor instance, when you ask a client what they would want to talk about/address during the coaching engagement or even a particular session and you find that they are all over the place and confused about how to proceed, the Wheel of Life can come to your rescue. And not just once, this tool can be used at regular intervals to assess where one is at life at different times and phases. Well, honestly, it is a tool that can be used by anyone and everyone, even by coaches themselves in their own lives. Additionally, it also helps them understand what areas of their life need their immediate attention by enabling them to rank them in order of importance.Ī) it is dynamic and needs to be constantly moving and not be stagnant, andī) for a wheel to function optimally, it needs to ‘roll’ in as friction-free manner as possible by having all facets of life functioning at a higher and equal level.Įmploying this tool throws light on the areas that are causing ‘life’ to not run as smoothly as it potentially could. Simply put, The Wheel of Life provides a way for a person to get an estimate or bird’s eye understanding of where they are in their current lives. Also called the Wellness Wheel, Life Balance Wheel, or Balance Wheel of Life, this is one of the tools most actively used especially by life coaches, so if you’re new to coaching and are looking to learn more about tools that you can add to your coaching process and methodology, then you’re in the right place! What Is the Wheel of Life? It helps provide a targeted view to know where to focus your energy to create change.The Wheel of Life is a personal development tool that late Paul J Meyer – a thought leader and coaching industry pioneer – conceptualised in the 1960s. The Wheel of Life exercise captures a snapshot of where your life is at today. And often one area of life might be thriving, while other areas need increased focus. ✅ Image files (PDF): Image files blank or with labels, for you to add directly to presentations, workbooks or internal documents as needed ✅ Reflection Questions (Microsoft Word): Simply add your brand and send to your coachee to complete ✅ Coaching Questions: For coaches, facilitators and people leaders to help guide coachees or employees through the process ✅ Editable Templates (Microsoft Word): Easy to use and ready to add your brand, including both a blank Wheel and an example that can be embedded in presentations or workbooks as needed ![]() ✅ Resource Guide: Instructions on how to use the model Here’s what your Wheel of Life download pack includes: ![]() ![]() ![]() ![]() The resistor reduces the peak input impedance of the filter at the cut-off frequency without affecting the cut-off frequency as long as the component values for the resistor and second capacitor are chosen correctly. Damped LC FiltersĪdding a second capacitor in series with a resistor across the input to the switching power supply immediately after the first main filter capacitor will change the filter to act as a parallel damped low-pass filter. A good rule of thumb is to aim for a minimum damping factor of 1/√2. Therefore, the designer needs to ensure that the values are selected such that a poor damping factor cannot result in oscillations within the switching circuit control loop. ![]() Component values will determine the cut-off frequency and the damping factor of the filter, the damping factor determining the attenuation characteristics at the cut-off frequency. The designer can trade-off performance against component size and cost to create an optimal solution.Īn inductor in series between the supply voltage and the input to the switching power supply combined with a capacitor across the input to the switching power supply will act as an undamped low pass filter. Passive LC filters can achieve the required results for input filtering in a relatively simple solution. However, an LC filter will offer considerable advantages that limit RC filter usage in performance and efficiency. It has an application in low-power solutions where cost and component size are significant constraints. The most basic input filter available is the RC filter. Thus, switching mode power supplies pose the most questions and test the designer’s skills the most regarding power supply filter design. Third, the input filter must prevent the switching circuitry’s noise from being conducted back through the power supply to the input power lines. Second, the input filter must prevent noise generated by the switching circuitry from appearing at the output. First, the input filter must prevent noise on the input power lines from being conducted through the power supply to the output. Switching power suppliers present the designer with a challenge when it comes to effective filtering. ![]() ![]() ![]() Ballou has also produced and co-produced several Converge albums, including 2001's Jane Doe, 2004's You Fail Me and 2006's No Heroes. Ballou has stated that because of the quality of recordings has improved so much that the original recordings were "becoming distracting". In 2005 Ballou remixed and remastered Converge's Petitioning the Empty Sky and When Forever Comes Crashing. Ellard jokingly stated Ballou "watched him like a hawk" during the engineering and producing process. Ballou handled all production, engineering, and mastering for the record.īallou has stated that collaborating on Jane Doe with co-producer Matthew Ellard was a huge learning experience for him as an engineer and producer. One of the earliest recordings from the studio was Cave In's Until Your Heart Stops. In regards to Ballou's technical precision as a producer, Jacob Bannon (of Converge) has stated, "Nothing gets by him-it is inspiring to watch him work." Įstablished in 1998, God City Studio is located in Ballou's home state of Massachusetts. His experiences and knowledge in engineering carry over to his recording work. Instead of selecting a different position within the same company that he had worked with for six years, Ballou opted to receive a severance package which he used to build his own recording studio. In the late 1990s, Kurt Ballou was working as a biomedical engineer when his then-project got cancelled. From 1999 to 2002 Ballou and Ben Koller played in the hardcore punk band Blue/Green Heart. In 1998 Ballou established GodCity Studio. From 1996 to 1999 Ballou and Stephen Brodsky played in the rock band Kid Kilowatt. From 1996 to 2000 Ballou played in the hardcore punk band The Huguenots. Since 1990, Kurt Ballou has played in the metalcore band Converge. ![]() He is a vegan and follows a straight edge lifestyle. His father used to have a guitar that Ballou played occasionally, but it did not interest him until a school friend gave him Slayer tapes around the age of sixteen. Ballou was accepted to join the Hartford School of Music, but he opted to study aerospace engineering instead. He performed in jazz band, concert band and orchestra, dabbling between baritone saxophone, bassoon and bass clarinet. Kurt Ballou started playing saxophone in elementary school. Kurt Ballou (born February 1, 1974) is an American musician and producer based in Massachusetts, best known as the guitarist for hardcore punk band Converge and for his prolific recording and production work at his own GodCity Studio. ![]() ![]() ![]() Other cherished highlights: Mother Courage & Her Children (performing & standby for Meryl Streep) at the Delacort Theater, Lady Macbeth of Mtsensk & Les Troyens for the Met Opera as well as Anyone Can Whistle, South Pacific, Sondheim! The Birthday Concert, and A Sondheim Celebration, all at Carnegie Hall. Additionally, Colleen has performed in Merrily We Roll Along, Do Re Mi, Strike Up The Band, & Call Me Madam for City Center Encores!. She has also appeared in the original Broadway casts of Cats, Into The Woods, Jerome Robbins’ Broadway, Passion, Lestat, and Road Show (Public).Ĭolleen is proud to have traveled the country with leading roles in national tours of Into The Woods, Hello Dolly! (w/ Madeline Kahn), Follies (Los Angeles) and as Donna in Mamma Mia! in the #1 Tour. Her New York credits include revivals of Follies, Sunday In The Park With George, Company, Bye Bye Birdie, and 110 in the Shade. Colleen is a Broadway veteran and vocal performance coach with over 30 years experience in theater, film & television. Follow on IG: victoriajclarkĬolleen Fitzpatrick (Standby for Kimberly)ĬOLLEEN FITZPATRICK ( Standby for Kimberly). Live while you’re living we have nothing but this moment. The last time she was 16, Clark played 71-year old Rebecca Nurse in her high school production of The Crucible. ![]() Her second solo disc-, a reimagining of Maury Yeston’’s acclaimed song cycle December Songs- expanded for 40-piece orchestra and conducted by longtime collaborator Ted Sperling- is due for release on PS Classics this fall. ![]() TV: Pose, The Blacklist, Almost Family, Homeland, and One Royal Holiday. Clark is also an avid educator and director. ), Cinderella (Tony nom.), Gigi (Tony nom.), and many Off-Broadway plays and musicals including Atlantic Theater’s production of Kimberly Akimbo for which she garnered the Lucille Lortel and Outer Critics Circle Awards. Since then she has starred in 11 Broadway shows including The Light in the Piazza (Tony, Drama Desk and Outer Critics Awards ), Sister Act (Tony, Drama Desk noms. Her first Broadway job was understudying in the original production of Sunday in the Park with George in this theater 37 years ago. VICTORIA CLARK ( Kimberly) is the Tony Award® Winner for Best Leading Actress in a Musical! She has packed a lot into her brief teenage life. ![]() ![]() ![]() ![]() Bitlocker Drive Encryption Hasleo Bitlocker Data Recovery. Top downloaded Bitlocker files for free downloads at WinSite. File Encrypt Decryption is a common encryption application used. M3 Bitlocker Decryption Free software supports to safely recover lost files from Bitlocker hard drive, to retrieve data from lost or deleted Bitlocker partitions. Fast downloads of the latest free software! Click now. How to activate BitLocker on Windows 8 / 10 for the Drive Encryption.ĭownload M3 Bitlocker Decryption Free 5.5.1 for Windows. Note- If the device was set up or BitLocker protection was. For more, see Device encryption in Windows. If you have a modern device that supports automatic device encryption, the recovery key will most likely be in your Microsoft account. In your Microsoft account- Sign in to your Microsoft account on another device to find your recovery key. i have tried to find it in controlpannel also but i fails. please help me i am unable to find bit locker drive encryption in my windows 8.1. Original Title- bitlocker drive encryption. Easily Lock and Unlock BitLocker-Encrypted Drives. Change Password for BitLocker-Encrypted Drives. Export BitLocker Recovery Key Startup Key. Decrypt BitLocker-Encrypted Windows Data Partitions. Hasleo BitLocker Anywhere#x27s key features include- Encrypt Windows C- Drive or Data Partitions with BitLocker Drive Encryption. ![]() A) At boot when prompted to plug in the USB flash drive that contains the startup key, click/tap on Press Esc for BitLocker recovery, and go to step 4 below. Do step 2 or 3 below depending on what you set to unlock your OS drive with. Hasleo BitLocker Anywhere has had 5 updates within the. In addition to password protecting a partition, you can even add one or more keyfiles to it for.īitLocker locked my external harddrive without being asked.ĭownload Hasleo BitLocker Anywhere for Windows to encrypt drive with BitLocker in Windows, easily lock and unlock BitLocker encrypted drive. It#x27s also really simple to use and has some pretty neat, unique features. It lets you encrypt the system/boot volume as well as any other internal or external hard drive. Using the Group Policy Editor to Enable BitLocker Authentication in the.ĭiskCryptor is one of the best free disk encryption program for Windows. > DOWNLOAD: Bitlocker drive encryption windows 8.1 free download Bitlocker drive encryption windows 8.1 free download JBitlocker drive encryption windows 8.1 free download ![]() ![]() After the forum installation, the forum information will appear on the list of plugin installed. If pulling was success full the plugin backend will now launch the App installation wizard just be following the wizard by filling forms and clicking next until the wizard complete the forum installation.Ĥ. Submit the form and wait for the backend to pull the forum plugin to your server.ģ. ![]() For the seck of this example I leave it as default name which is forum, becasue we are installing forum plugin, but you change the folder name. Install path: you can change the installation folder name. Like below image.įill the form with this information below. Click on New plugin button and a pull form will popup. Important: Should assign your database username the previllage to create database tables.Ģ. Create an empty database on from your server cpanel and write down the hostname, username and password of the database. Last two weeks I informed the house of a forum application I developed which I shared the link some time ago,įrom your plugin backend application, you can install the forum on your server without writing any programming code. The plugin backend is the main backbone of the application, as with it you can install new plugins, uninstall plugins, access plugin admin panel, generate mobirise intergration code. Please remember this information as you will need it to access your backend. This will enable you protect your backend with username and Password. Click on start button and you will be redirect to setup admin access. After the successful plugin pull the extension will install the application to your server and now show start button. Submit and wait while the extension pull the plugin from my server. Now let's use the extension to pull our first application called plugin backend. Now the extension have generate the required files to pull application plugins from any plugin vendor.ĥ. Publish your website to an enabled php server visit the page on your website. The extension will display just an application pull interface. Install the extension on your mobirise 4.11.xxģ. Download the extension with the download link in the first post.Ģ. In a marketing email, and in the app itself, the description under the All-in-One Kit states, 'Get ALL current and future Mobirise themes and extensions …’, but an almost hidden FAQ says that you only get new add-ons for one year from purchase.1. ![]() (Your mileage may vary.) If you do decide to pay for additional themes and extensions (unnecessary IMO) make sure you understand the licensing. Searching the exported code for ‘mobirise’ is worth the effort! The app includes a built-in FTP client, but in my testing it was pretty broken. (In some ways this is both the app's greatest strength and weakness.) You need to be careful to look over every element before publishing your site-pre-made components contain alt tags and links to Mobirise, some of which are all too easy to overlook. You can turn elements off and on, change alignment of text, and other basic options like that. Cons: If you're a designer, or anyone who likes to have full control over the look of your design, Mobirise probably isn't for you. ![]() ![]() Sakura Dungeon differs from its visual novel counterparts (excluding Sakura Clicker) in that it is a first-person dungeon crawler that shares similarities to the Lightning Warrior Raidy series and especially Demon Master Chris (Warning! Link is NSFW). The main protagonists are Yomi and Ceri but the story is told from Yomi’s perspective.Įxample of a dungeon floor first-person view. ![]() She soon discovers that it was a heroic knight named Ceri who woke her from her slumber, and after a brief fight and “negotiation,” the knight decides to join her on an adventure to reclaim the dungeon! Plot Summary: In this story players will assume the role of an ancient fox spirit named Yomi who awakens after several hundred years of deep sleep to find that possession of her lovingly made dungeon has been taken from her! As if that wasn’t enough cause for alarm, she has also been robbed of her power, leaving her weak and vulnerable. Length: 20+ hours for the main story (Give or take) and 5-10 for the extra content. Themes: Monster Girls, Animal Girls, Ecchi, Fanservice, Yuri Genres: RPG, First Person, Dungeon Crawler, Note: I played through the game with the uncensored patch but the review will feature images from the censored version. Is the game worth checking out for yuri fans who enjoyed Sakura Fantasy? Let us find out as we take a look at Sakura Dungeon, published by Sekai Project, Denpasoft and Nutaku. While waiting for that sequel something unexpected came up, another 100% yuri Sakura game. Still waiting for Chapter 2! I heard Sakura Beach and Sakura Swim Club feature content worthy of the Yuri Nation’s attention but since the main protagonist is male I did not bother. The last time I had done so was Sakura Fantasy Chapter 1. It has been a while since I last reviewed a game from Winged Cloud‘s ongoing Sakura franchise. ![]() When she isn’t scuppering well-laid plans by charging in like a lunatic, that is.Note: Review copy provided by Sekai Project. ![]() Scarlet is a fierce fighter who’s an asset to have on the battlefield… She’s a perpetually cheerful foxgirl who fancies herself as a brave knight, who was kicked out of her former party for being a little too enthusiastic while fighting monsters. Scarlet is the third addition to Mina’s party, and she she has no shortage of energy. She’s determined to find Luna again, no matter how long it takes, and she doesn’t care who she drags along with her. Mina is cold and aloof to most people, but she absolutely adores Luna. As a result, she can come across as being arrogant. She’s aware of her own strengths and she doesn’t try to downplay them. Mina might be a prodigy, but she’s proud and haughty alongside it. Mina is a highly talented mage, and she’s the catalyst behind this tale. It’s been a long time since she last wielded a blade, however, and Aki isn’t too confident about her abilities. Bullied by her co-workers and criticized by her parents for her lack of ambition, Aki struggles to see herself as a warrior.Ĭontrary to her demure appearance, however, Aki is handy with a sword, being a kendo champion in her teenage years. She’s quiet and soft-spoken, and she finds it hard to assert herself. Attacked by thieves, assaulted by slimes, and encumbered by Aki’s own incompetence, Aki’s new life in Anthem gets off to a poor start.Ĭan an awkward, unassuming office lady like Aki really become a hero?Īki is the unwilling heroine of our tale. Our trio’s journey will be far from easy, however. Mina enlists the help of Aki, our heroine, and Scarlet, a cheerful foxgirl, to track down Luna and punish the brigands who kidnapped her. The priestess Luna, whom Mina was entrusted with taking care of, has been kidnapped by malevolent forces, and Mina has no idea where she is. ![]() She promises she’ll return Aki home in due course, after she’s had a chance to replenish her magical energy, but she wants Aki to do her a favor first. Mina is a talented mage whose skills far outstrip most others. Aki isn’t exactly happy with her lot in life, but it’s all she knows, and she’s too tired from work to change it.Īki is the last person you’d expect to go on a magical adventure…Īfter being mown down on her way home from work, Aki is summoned to the land of Anthem by a cat-eared witch called Mina. She lives in Tokyo, works at an office, and she whiles away her time playing MMOs. Aki’s life is nothing to write home about. ![]() ![]() ![]() Notice I was able to choose a color for the background/ paper color! (creamy) I added white highlights for “pop” by using an opaque white over the base colors and marker tools ( see the tools in the image above, the toolbar appears to the left) to add the African/ Ankara print motif and colors (I actually usually use colored pencils for that instead now). Most apps for fashion illustration have a great black brush tip ink pen tool. A black “f elt tip pen” tool is used for all of the lines. Here you can see I used an alternate paper color, and the watercolor (used on the skin tone) tool’s texture and also the sheer, smooth marker tool i used for the yellow fabric. Tools I used in the Tayasui app for fashion illustration: I like to sketch first in light pencil, then follow up with ink pen and paint over that. I want show you the soft grittiness of the pencil and range of light to darks. Here is a step by step example of one of MY VERY FIRST fashion illustrations “growing ” in Tayasui Sketches app. I also recommend it to you because it is clean, easy, i ntuitive, natural, a total joy to learn. I’m someone who always strives to keep the tactile look and feel of real art supplies in my digital fashion illustration, and that’s why Tayasui Sketches Pro app is my first choice of apps for fashion illustration. cut and paste portions of your drawing to duplicate, shrink or rotate them.if you want to, and you can also RECORD YOUR DRAWING PROCESS in real time with or without sound, and play it back later!. ![]() SHARING DIGITAL WORK looks bright and clean on socials! You can easily share your work via social media or export to photoshop or camera.like little moleskines that you can use to organize your work, and put labels and titles on them! It also has various digital “sketchbooks”.It even has sound effects if you want them on! a viscerally textural feel (if and when you want that like I do) that really looks and feels like gritty, sensitive pencil, watercolor, brush pen, ink etc. ![]() VERY easy to access and select tools menu interface.textures and patterns such as watercolor for filling shapes.*** psssssss…you can learn to draw and paint right away in each of these beautiful apps in my ABOUT FACES digital course.****įor the classic artist, freehand fashion illustration feels the most natural and organic like gouache and pencil on your digital device when you use Tayasui Sketches… a VERY affordable, and VERY flexible app for fashion sketching with tools that many other apps don’t have, such as Though I’ve moved up to an iPad Pro for my fashion illustration and art, it really hasn’t changed much in my approach… just a larger screen. I’m a classic gouache and pencil, Parsons-trained, old-school fashion sketcher and illustrator, and I only wanted to experience rich texture and grit on my ipad that would feel as closely as possible to working organically on illustration paper with wet gouache. Personally, I first started illustrating digitally a few years ago using an iPad MINI with apps in 2015 after resisting them for a long time and was thrilled with the results when I finally fell in love with them. Here are my discoveries about the 3 best fashion illustration apps- IN MY EXPERIENCE–to share with you so you can thoroughly enjoy fashion sketch ing on your iPad or Android device! ( videos included further down )Īll of the recommended apps are available on Google Play and App store, so 3 best fashion illustration apps are available for both operating systems (My 2 above Illustrations using Tayasui Sketches) The Fashion Designer’s Reference and Specification Manual.Translations of my book: The Language of Fashion Design: 26 Principles Every Fashion Designer Should Know by Laura Volpintesta.FALL/WINTER PORTFOLIO DEVELOPMENT and TECHNIQUES.ALL INCLUSIVE- ALL ACCESS FREEDOM FASHION SUITE OF COURSES.FASHION DESIGN INFUSION 8 Masterclasses bundle.ORIENTATION: FUNDAMENTALS ONBOARD EXPERIENCE.SWATCHES TO GOUACHE design and illustration technique capsule course. ![]()
![]() ![]() These children experienced similar outcomes to the children treated with cells that were not frozen. Ten of the children in the study were treated at UCLA using a frozen preparation of corrected stem cells. Over 200 patients with various genetic conditions across the world have now been treated with this type of gene therapy – this is another very significant breakthrough.” Prof Adrian Thrasher, Professor of Paediatric Immunology at GOSH and Wellcome Principal Research Fellow, said “We started gene therapy at GOSH around 20 years ago and now have refined the process to offer a potential cure for children born with this debilitating condition. We need and want guidelines to change so we can start offering this potential cure to children and provide it as a first-choice treatment – this research could set those wheels in motion.” These corrected stem cells are then returned to the patient where, once engrafted, they go on to produce a seemingly continual supply of healthy immune cells capable of fighting infection.ĭr Claire Booth, co-lead author, Mahboubian Associate Professor in Gene Therapy and GOSH consultant in Paediatric Immunology and Gene Therapy: “If approved in the future, this treatment could be standard for ADA-SCID, and potentially many other genetic conditions, removing the need to find a matched-donor for bone marrow transplant and the toxic side effects often associated with that treatment. Next, a viral vector is used to deliver a new copy of the ADA gene into the DNA of the patient's cells. The gene therapy approach described in the paper involves first removing some of the patient's blood-forming stem cells, which create all types of blood and immune cells. Now, lentiviral gene therapy technology has advanced significantly and offers the potential to improve the safety and efficacy profile of this treatment option for patients. In earlier trials of gamma-retroviral gene therapy for other similar diseases, serious side effects including leukaemia have been seen in some patients. Everything had to be highly sterilised to keep her safe Sarah's mum, Maria. I wasn’t allowed to kiss my daughter or sleep next to her. “I now know how it feels to have your child as a patient and to be so sick, and I want to use my experience to help others in a similar position.” Sarah’s treatment has had a huge impact on the whole family, but it also inspired Maria to go back to studying and train to become a nurse. She’s doing so well now and can do everything a normal child her age would do.” Six months after she was given the gene therapy her skin was clean and healthy and the other symptoms got a lot better. “Before, her nappy rash was always bleeding and sore, she was being sick and losing weight. Sarah was referred to GOSH for gene therapy and several years after her treatment is doing very well: It was horrible to not be able to do normal things with my own daughter.” Everything had to be highly sterilised to keep her safe. I saw it was SCID and I was incredibly upset… I wasn’t allowed to kiss my daughter or sleep next to her. “I remember the exact time I saw the paper that had the blood test results on and the diagnosis. She was less than ten days old when her mum Maria became concerned about her daughter’s weight loss and sore, bleeding nappy rash that wouldn’t heal. One of the patients treated was four-year-old Sarah from South Yorkshire. In the two cases in which treatment wasn’t successful, both children were able to return to current standard treatments, with one eventually receiving a bone marrow transplant.No serious side effects have so far been reported, with generally mild or moderate complications experienced from the necessary preparation for the gene therapy. Of these, 48 are no longer showing symptoms of ADA-SCID, although they will have lifelong monitoring. Two to three years after the treatment, all of the 50 children treated with the new gene therapy at Great Ormond Street Hospital, UCLA Mattel Children’s Hospital and the National Institutes of Health (NIH) are alive and well. ![]() If approved, gene therapy would be a welcome new treatment option for ADA-SCID as it is a one-time procedure that has the potential to provide life-long results. These treatments are expensive and therefore out of reach for patients in many countries. If a matched bone marrow donor is not available, patients require lifelong ADA injections along with preventative medicines. The standard treatment for ADA-SCID involves once or twice weekly injections of the ADA enzyme until a matched bone marrow donor – usually a close family member – can be found. In a new study published in the New England Journal of Medicine, co-lead authors Professor Donald Kohn (UCLA) and Dr Claire Booth (GOSH) reported the two- to three-year outcomes of 50 children who were treated in clinical trials with an experimental stem cell gene therapy for ADA-SCID between 20. ![]() |
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